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Muscles that support the knee—primarily in the legs and hips—need a certain amount of elasticity to work properly. That "give" allows the joints to move through their range of motion easily. If the muscles are tight, they might cause chronic knee pain. Stretching leg muscles can improve flexibility and reduce knee discomfort. Experts recommend doing dynamic stretching before workouts and static stretching afterward. One should consult a doctor if pain persists after a few weeks.

Braces help some people cope with the pain, swelling, and stiffness of knee osteoarthritis. Examples include a knee sleeve, a compressive or stretchy tube that provides warmth and might help reduce knee swelling; an unloader brace, a long frame that fits on top of the leg and helps reduce pain by redistributing pressure on the knee; and a patella tracking brace, which combines the approaches of both knee sleeves and unloader braces to reduce knee pain, swelling, and pressure at the kneecap (patella).

Annually, about 790,000 Americans (about 60% women) undergo knee replacement surgery. Women are more likely to have arthritis, the main culprit leading to most knee replacements. Before surgery becomes an option, people first need to try conservative treatments such as pain relievers, injectable medications, and physical therapy. Signs a knee replacement may be necessary include pain that hinders people from doing basic activities, unstable walking, and needing multiple medications to function.

A 2024 study found that low-dose aspirin therapy was more effective than taking anticoagulants for reducing the risk of blood clots following a total knee replacement surgery. Aspirin therapy also caused fewer bleeding complications.

Regular exercise and stretching can reduce knee pain related to some common conditions. Exercises that strengthen muscle groups in the upper and lower legs, hips, and core can help them better support the knee and improve movement. Strength-building exercises should be done at least two days a week, and stretches should be performed daily.