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A 2024 study found that people who follow a diet with a higher ratio of plant-based protein to animal-based protein may have a lower risk for cardiovascular disease and coronary artery disease compared with individuals who eat a lower plant-to-animal protein ratio.

Having type 2 diabetes doubles a person's odds of heart disease, and this risk may be present as early as 30 years prior to the diabetes diagnosis, according to a 2024 study. The findings support the long-held observation of the shared underlying causes of diabetes and heart disease. These include factors that contribute to both conditions, especially the tendency to accumulate fat in the middle of the body, known as abdominal obesity. This problem tends to occur in tandem with high blood pressure, unhealthy lipid levels, and elevated blood sugar—a cluster of signs and symptoms called metabolic syndrome.

High levels of Lp(a)—a fatty particle similar to LDL cholesterol—may double or triple a person's risk of a heart attack. About one in five adults may have elevated levels, which also raises the risk of stroke and aortic stenosis. Unlike LDL, which rises with age and is influenced by diet and exercise, Lp(a) remains largely constant over a person's lifetime, so a one-time test suffices for screening. Lp(a) testing is becoming more common now that five promising new Lp(a) therapies are in development.

Broken heart syndrome (officially known as takotsubo syndrome) causes symptoms similar to a heart attack. While intense emotional stress can trigger the condition, physical stressors such as surgery or severe illness are more common causes. Most cases occur in women, but proportion of cases recognized in men has risen in recent decades. Most people fully recover within weeks to months. But those who also have other serious health conditions may face a higher risk of dying within two months after being diagnosed with takotsubo syndrome.

Both the Mediterranean diet and vegan diet can help stave off heart disease. But while the Mediterranean diet is slightly more expensive than the standard American diet, a vegan diet is 19% lower in cost, according to a 2024 analysis.

Although doctors and patients rarely talk about it, cardiovascular disease and its treatment can affect sexual function. Atherosclerosis can affect arteries that supply blood to the genitals, and high blood pressure medication can cause sexual side effects. Certain medications used to treat common sexual issues (namely, erectile dysfunction drugs and some types of estrogen) may be unsafe for some people with heart disease.

A 2024 study of more than 200,000 adults, combined with findings from 19 other studies (for a total of 1.25 million people), tied eating ultra-processed foods—particularly sugary drinks and processed meats—to an increased risk for heart disease.

Anti-obesity drugs, which can lead to dramatic weight loss, may improve symptoms of sleep apnea. This serious breathing disorder raises the odds of high blood pressure, heart attack, and stroke. Excess weight is the strongest risk factor linked with sleep apnea, which affects about 25% of men and 10% of women in the United States. Extra fat tissue in the neck and throat can narrow the airway, and extra weight on the chest and belly puts pressure on the lungs, which makes the normal process of inhaling and exhaling less effective.

According to a 2024 study, eating foods rich in beneficial plant compounds called flavonoids may lower the risk of atherosclerosis in the arteries of the legs and neck. Good sources of flavonoids include tea, apples, pears, peaches, and oranges.

Many Americans may have a potentially serious condition marked by a buildup of fat inside the liver. Known as metabolic dysfunction–associated steatotic liver disease (MASLD), it's closely linked to a higher risk of cardiovascular disease. The root of the problem is usually excess weight—especially the accumulation of belly fat known as abdominal obesity. Weight gain can trigger a host of metabolic problems that cause blood sugar, blood pressure, and cholesterol levels to rise. All of these factors are closely linked to a higher risk of diabetes and cardiovascular disease. Heart disease is one of the common causes of death among people with MASLD.