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Tens of millions of people who've had COVID-19 suffer with persisting symptoms. The condition is called long COVID. Symptoms, such as fatigue, difficulty concentrating, and disrupted sleep, can seriously impair the ability to function at work and at home. Vaccines and antiviral drugs appear to offer some protection against getting long COVID. But more information is needed. The National Institutes of Health has committed over $1 billion to discover how to better diagnose, effectively treat, and ultimately prevent long COVID.

COVID-19 may increase the risk of cardiovascular problems, including heart attack, stroke, pulmonary embolism, atrial fibrillation, and heart failure, up to a year after the infection. But vaccination appears to lower these risks. Getting just one dose of a COVID vaccine may halve the risk of myocarditis, a rare condition that causes inflammation of the heart muscle that can arise after viral infections.

There are currently nine trials of vaccines for Alzheimer's disease under way. All of them are in people with mild Alzheimer's or with the pre-Alzheimer's condition called mild cognitive impairment. All of the vaccines are designed to encourage the immune system to remove protein deposits from the brain. Most experimental vaccines are given by injection; one being tested at Harvard Medical School uses a nasal spray. It will be several years before we know if any of them will work.

With influenza virus, a new vaccine must be developed each year to adapt to the virus's changing structure.

Getting at least one dose of a COVID vaccine lowers the risk of developing long COVID even among people who were previously unvaccinated and recovered from COVID.

A 2022 observational study that included more than 200,000 people found that those who'd had shingles at some point had a 30% higher long-term risk for a major cardiovascular event, compared with people who didn't have shingles.

Cervical cancer is curable when caught early through routine screening, so research showing a surprising rise in advanced cancer cases in some groups is worrisome. Two Harvard experts share insights about the research and advice on how people can best protect themselves.

The routine yearly medical check-up is now more often referred to as the annual wellness visit, which allows people to formulate detailed health goals with their doctor and design plans to meet them, as well as assess the possibility of life-changing events, like heart attack, stroke, and cancer.

Arm tenderness is the most common side effect after vaccination. The injection stretches muscle fibers and triggers an immune response, causing discomfort. People can counter pain by moving the injected arm afterward and applying a cool compress or ice pack.

Another holiday season is here, and this year we need to contend with other viruses besides COVID-19. Three Harvard experts share their thoughts on the best ways to keep ourselves and our family members healthy as we celebrate holidays together.