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Ketamine has been used for decades as an anesthetic, and in 2019 an inhaled version of it was approved by the FDA for treatment-resistant depression. But it is generally prescribed only when other treatments have not been effective.

Many medications claim to relieve migraine pain, but some are more helpful than others. In a large study looking at real-world data on 25 drugs, migraine sufferers rated the most and least helpful options.

For people older than 75 who have heart disease already, or who are at increased risk of developing heart disease, there now is solid evidence that statins remain effective at lowering cholesterol and, more important, in reducing the risk of new or recurrent heart disease. For people older than 75 who have not been diagnosed with heart disease and are not at increased risk for developing it, the value of statins still is uncertain.

The weight-loss drug semaglutide is the first obesity treatment shown to help people live longer and have fewer cardiovascular problems. Developed as a drug for type 2 diabetes, semaglutide was first marketed as Ozempic; a higher-dose version for weight loss is called Wegovy. But because the drug is so popular, it can be hard to find, and it might not be covered by insurance.

A 2023 study suggests that taking low doses of amitriptyline, a tricyclic antidepressant also used to treat nerve pain, may be one of the best pharmacologic choices to help improve symptoms of irritable bowel syndrome.

Falls are the leading cause of injuries and accidental deaths among Americans 65 and older. Women fall more often than men and are far more likely to show up at an emergency room because of a fall. Women are especially vulnerable to falling due to weaker bones, lower muscle mass, higher rates of incontinence and antidepressant use, and a tendency to multitask. People can reduce their fall risk by doing strength and balance exercises, getting regular vision and hearing exams, reviewing their medications, and keeping floors clutter-free.

Pharmacies across the United States are struggling with budget cuts and staffing shortages. As a result, customers are sometimes experiencing delays in getting their prescriptions filled. Until pharmacies resolve their challenges, customers might need to work a little harder to get their medications promptly. One strategy that can help is ordering prescription refills early. If customers continue to have frequent delays at their pharmacies, they might consider switching their prescriptions to another store.

Night blindness makes it hard to see in dim or dark settings, which can affect safety at home and make driving dangerous after dark. While the cause varies, there are steps people can take to address these problems.

The cost of a prescription drug can be very high, and several factors contribute to this. What can consumers do to reduce their drug costs, and what changes need to be made to make medications more affordable?