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Medications Archive

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More people are using aspirin therapy

Daily aspirin use has increased among U.S. adults, according to a survey published May 2015 in the American Journal of Preventive Medicine. The survey asked more than 2,500 people ages 45 to 75 about their current aspirin use. The overall use was 52%, up from 41% in a similar survey in 2004. The most common reasons for taking daily aspirin were prevention of heart attack and stroke. Eighteen percent of aspirin users cited cancer prevention as their reason for taking aspirin. And while most users said they'd talked to their doctor before starting aspirin therapy, 25% of the respondents had not. That finding is troubling, since aspirin is a blood thinner. "Aspirin can increase the risk of bleeding in the brain or elsewhere in the body.ÌýThis risk might be justified if there is a good reason for aspirin use, but might be entirely unjustifiable if not. That is why I always recommend discussing any medication or supplement use with one's primary care provider," says Dr. Natalia Rost, associate professor of neurology at Harvard Medical School.â€�

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There is something you can do about Alzheimer's disease-join a study

Thousands of volunteers are needed for current Alzheimer's studies.
Image: Thinkstock

Women are at greater risk for dementia. Joining clinical trials can help to speed the development of promising drugs.

IV osteoporosis drug builds bone in older women who can't take the oral version

A study published online April 13, 2015, in JAMA Internal Medicine indicates that a single infusion of the bisphosphonate drug zoledronate (Reclast) can be used to increase bone density in women who can't take oral versions of bisphosphonates. Taking an oral bisphosphonate like alendronate (Fosamax) is effective in building bone for women with osteoporosis, but it requires a commitment—taking the drug on an empty stomach and remaining upright for 30 minutes afterward. Because this may not be practical for women in assisted living facilities, they often aren't given bone-building drugs, even though their risk of hip fracture is eight to nine times that of women living at home.

The researchers studied 181 women with osteoporosis residing in assisted living facilities. The average age was 85. The women were randomly assigned to one of two treatments�1,200 milligrams of calcium and 800 IU of vitamin D daily as supplements plus a single intravenous infusion of zoledronate or the same daily doses of the supplements alone.

Can you put off that knee surgery?

Don't assume surgery is necessary if knee pain sidelines you. Physical therapy may be all it takes.

Image: iStock

Physical therapy and weight loss can relieve knee pain and protect your mobility.

Ask the doctor: Prostate surgery and ED

Q. I am scheduled to have my prostate removed and am concerned about the risk of erectile dysfunction (ED) after the surgery. I've heard that taking an ED drug daily during my recovery could help. Do you recommend this?

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A. About half of men lose some erectile function after radical prostatectomy, which removes the entire prostate gland. ED drugs help men to have erections after surgery, but so far research has not shown that taking it daily produces better results than taking the medication as-needed—when you anticipate sexual activity.

Gain more weight, get more GERD

Maintaining a healthy weight is the best way to rein in gastroesophageal reflux disease (GERD), or chronic heartburn, according to a study in The American Journal of Gastroenterology. Researchers found that GERD symptoms increased for every incremental rise in body mass index (BMI), which measures the ratio of weight to height.

In GERD, the acidic contents of the stomach back up into the lower esophagus, causing burning pain. The most effective treatment for GERD is taking an acid-reducing proton-pump inhibitor medication, such as omeprazole (Prilosec). People who are overweight are much more likely to develop GERD.

Adding folate to blood pressure medication reduces stroke

People with high blood pressure could benefit from a B vitamin known as folate if they are not getting enough from their diets, according to a study in The Journal of the American Medical Association (JAMA).

The study included more than 20,000 adults in China with high blood pressure who had never had a stroke or heart attack. Participants who took folate supplements along with a blood pressure medication had fewer strokes over the four-and-one-half-year trial than those who only took the medication.

Most liver risk comes from over-the-counter drugs and supplements

Many different medications can potentially harm the liver, so doctors sometimes do liver function tests to ensure safety. The worst-case scenario is liver failure, but when this happens, the cause is usually not prescription medications, but rather the over-the-counter painkiller acetaminophen (Tylenol) or herbal supplements, according to a study in Gastroenterology.

Researchers scrutinized 5.4 million records of patients in the Kaiser Permanente Northern California system from 2004 to 2010. They identified only 62 cases of liver failure, 32 of which were linked to medications. This may not precisely reflect national rates, but it does suggest that liver failure from medications is relatively uncommon.

Acetaminophen seems safe for the heart

After a small study hinted that taking acetaminophen (Tylenol) might increase blood pressure, some doctors worried that this popular painkiller might not be as safe as once assumed, particularly for people with heart disease. But those fears now appear unfounded, according to a March 2015 report in Hypertension.

Using records from a U.K. health database, researchers identified nearly 25,000 people ages 65 and older with high blood pressure. They then compared people who took acetaminophen with people who didn't take the drug over a 10-year period. After adjusting for possible confounding factors, they found no elevated risk of heart attack, stroke, or any cardiovascular events among people who used acetaminophen—even among those who took the painkiller frequently. Despite this reassurance, be aware that high doses of acetaminophen can damage your liver. Don't take more than 3,000 milligrams (mg) a day. Over-the-counter pills (including some cold and flu drugs) may contain up to 650 mg of the drug, so check labels carefully.�

Adding a diuretic to your blood pressure drug

Diuretics can augment the blood pressure-lowering effects of other drugs, such as ACE inhibitors.

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It may boost the effect of your current medication.

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