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Tau proteins, and not necessarily beta-amyloid, may be the key to unlocking a viable treatment.

Alzheimer's disease affects more than five million people, and that number is expected to more than double by 2050. While there is no cure, attention has refocused on what many researchers believe is a major player in Alzheimer's: tau proteins.

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Is heart disease in your genes? And if so, can you do anything about it?

Cardiovascular disease continues to be the No. 1 killer of men, and while strides have been made to reduce the risk of heart attack and stroke, one area that remains elusive is genetics.

This common inflammation of the joints can be treated and managed with medication and lifestyle changes.

Gout affects more than eight million adults, six million of whom are men. It often strikes suddenly, like flicking on a light switch, and the pain is severe, with intense swelling and redness.

Food choices can dictate if you get gout, as high intake of organ meat, shellfish, and alcohol can raise your risk. But diet is only a part of it. "There is a direct relationship between advancing age and gout," says Dr. Robert Shmerling, clinical chief of rheumatology at Beth Israel Deaconess Medical Center.

Ask the doctor

Q. A test showed a 50% blockage in one of my major heart arteries. That sounds pretty bad to me, but the cardiologist said I didn't need a stent. Why?

A . Your reaction is not unusual. Many people find it hard to understand why that degree of blockage wouldn't be treated with a stent—a tiny, flexible mesh tube that props open a newly cleared artery. But while stents can be helpful, they're not risk-free. The procedure to open the artery (angioplasty) involves threading a balloon-tipped tube from the wrist or the top of the thigh up to the heart. Minor risks include discomfort and bleeding at the insertion site. Rare but more serious risks (such as a heart attack) occur in about 3% of people undergoing the procedure. And to prevent blood clots at the stent site, people need to take anti-clotting medications for up to a year afterward.

Peripheral artery disease can be debilitating and dangerous.

Most often, concern about atherosclerosis (when fatty deposits clog arteries) centers on the coronary arteries, which serve the heart. But the arteries outside the heart—the so-called peripheral arteries—are also vulnerable.

When you're active, your leg muscles need extra oxygen. But narrowed arteries in the legs can't deliver enough blood and oxygen to keep up with the demand. The result is pain in the calf, thigh, or buttock while walking that goes away with rest. Known as claudication, it's the classic symptom of peripheral artery disease (PAD). But many people with PAD either don't have symptoms or mistake them for another problem. As a result, PAD often goes unrecognized.

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Devices to treat nighttime breathing problems may help lower blood pressure and reduce the harm to your heart.

Peaceful slumber is often a pipe dream for people with obstructive sleep apnea. More than 25 million Americans have this problem, in which the tongue or throat tissue temporarily blocks the airway during sleep. The resulting pauses in breathing (called apneas) lead to explosive snoring or gasping for breath—sometimes more than 30 times per hour.

Ask the doctor

Q. My right hand goes numb when I open a can or use hand tools. Is this something I need to worry about? Do I have carpal tunnel syndrome?

A. The hand receives its sensory information from three different nerves, and irritation of any of them can lead to numbness. In the hand, numbness is often related to the way that the nerve is compressed or squeezed slightly when you bend your wrist, as happens when you open a can. Excess vibration or repetitive hand motion when you use tools may also cause numbness.

If knee pain and swelling are severe an are not getting better, see your primary care doctor for a thorough evalucation. Image: Thinkstock

Arthritis is not the only possible cause of knee pain, swelling, and disability.

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Clots in the lungs are twice as deadly as heart attacks.

If you scrape your leg, blood clots come to the rescue to heal the wound. But if a blood clot forms deep inside a leg vein, it's a different story. Known as a venous thrombosis—a term meaning "blood clot in a vein"—this type of clot can cause pain, swelling, and redness in the affected limb. When one forms in a leg or arm, it's called deep-vein thrombosis (DVT). But the real threat happens if the clot breaks off and travels to the lungs, causing a pulmonary embolism.

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Squeezing chest pain isn't always from a blocked artery.

Classic heart attack symptoms—severe pressure, heaviness, or pain in the chest—most often arise from a blockage in a coronary artery that prevents blood from reaching the heart muscle. But a lesser-known condition, called takotsubo cardiomyopathy, can produce the same sudden heart symptoms even when the coronary arteries are clear.