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Q.ÌýI've been taking Prilosec for many years for GERD. Recently, I once read that long-term use of proton pump inhibitors could increase the risk of stomach cancer. Your opinion?

A.ÌýPrilosec is a pump inhibitor (PPI). These drugs have revolutionized the treatment of gastroesophageal reflux disease (GERD), in which stomach acid flows back into the esophagus and causes heartburn.

The first accurate medical discussion of psoriasis dates back to 1801, but the disease itself is much older. In fact, its very name is borrowed from an ancient Greek word meaning an itchy or scaly condition. About 7 million Americans are plagued by this itching and scaling, and many of them have serious complications involving other organs. Although psoriasis is classified as a dermatologic disease, it doesn't start in the skin, and its damage may be more than skin deep.

Beneath it all

At a basic level, psoriasis is a disorder of the immune system. White blood cells called T-helper lymphocytes become overactive, producing excess amounts of cytokines, such as tumor necrosis factor, interleukin-2, and interferon-gamma. In turn, these chemicals trigger inflammation in the skin and other organs. In the skin, the inflammation produces three characteristic findings: widened blood vessels, accumulation of white blood cells, and abnormally rapid multiplication of keratinocytes, the main cells in the outer layer of the skin. In healthy skin, keratinocytes take about a month to divide, mature, migrate to the skin surface, and slough off to make way for younger cells. But in psoriasis, the entire process is speeded up to as little as three to five days. The result is thickened, red skin that sheds silvery scales of keratinocytes that have matured before their time (see Figure 1).

Water's good. Sugar-free gum helps. But Listerine may give you a dry mouth.

Saliva is like a health drink for your teeth and mouth. The three pints produced by the salivary glands each day contain antibacterial substances that protect teeth from cavities. Saliva contains calcium and phosphorus that teeth absorb. It also functions as an overall lubricant for the mouth, preventing food from sticking to your teeth and gums. By neutralizing gastric acid and keeping the flow of food and drink through the mouth and esophagus on the right course, saliva may help check gastroesophageal reflux (GERD), a leading cause of heartburn.

Q.ÌýMy platelet count has always been on the low side â€� 110,000. I don't have any symptoms. But a recent lab report mentioned "giant platelets." Is this something to worry about?

A.ÌýPlatelets are tiny cell fragments that circulate in the blood and help it clot. They form clots by sticking to one another and by releasing chemicals that promote other aspects of clotting, which is an elaborate, multistep process.

Q.ÌýI've tried a lot of things for a fungal infection in one of my toenails, but it just won't go away. What do you know about laser treatment for toenail fungus?

A.ÌýTwo lasers using different types of laser energy have attracted attention as treatments for fungal infection of the toenails, a condition called onychomycosis (pronounced oh-nee-koh-my-KOH-sis), which can also affect the fingernails. The theory is that a precisely directed laser can eliminate the fungus without harming the surrounding nail tissue. The underlying technologies are already in use for other conditions, including cataract surgery, dental work, and hair removal. Although there is some laboratory evidence that lasers can squelch fungal organisms, clinical studies in humans thus far are limited.

Heart and lung issues are often to blame for breathlessness. But an accurate diagnosis may require advanced testing.

Like your heartbeat, the regular inhale and exhale of your breathing is something you usually don't notice � until something doesn't feel quite right. Shortness of breath can result from a range of problems, including an allergic reaction, an anxiety attack, or anemia. But most often, the underlying cause is a heart or lung condition.

"Because these two organ systems are so intertwined, one always affects the other," says Dr. Aaron B. Waxman, who directs the Pulmonary Vascular Disease Program at Harvard-affiliated Brigham and Women's Hospital. In fact, about 60% of people with heart disease also have a lung disease. As a result, it's not always easy to distinguish cardiac and pulmonary issues, he says.

On call

Q. I've had a salty taste in my mouth for the past few months. Is there anything I can do about it?

A. The salty taste could be due to your taste buds becoming more salt sensitive (often a medication side effect), or a higher concentration of salt in your saliva, which can happen if you get dehydrated. Other causes of a salty taste could include

The condition causes leg pain and fatigue that make activity difficult, but lifestyle changes can improve how you feel.

The occasional leg pain or stiffness is often not cause for concern, but if pain or fatigue develops after just a few minutes of walking or climbing stairs, it could be an early sign of peripheral artery disease (PAD).

"PAD not only interferes with an active lifestyle, but also can put you at higher risk for a heart attack and stroke," says Dr. Michael Belkin, chief of the Division of Vascular and Endovascular Surgery with Harvard-affiliated Brigham and Women's Hospital. "You can't cure PAD once it occurs, so you want to take measures to avoid it as much as possible."

Here's how to protect yourself from this growing tick-borne disease.

Summer is the ideal time to enjoy the outdoors, but while you're interacting with nature, you need to look out for ticks that carry Lyme disease, the most common tick-borne disease in the United States.

About 300,000 people are diagnosed with Lyme disease each year, according to the CDC, and new research suggests that number will rise by 20% by mid-century.

Proper eye care can limit vision loss from most glaucoma � and prevent one of its most serious forms.

Glaucoma is a group of eye diseases that cause vision loss and blindness through damage to the optic nerve. Several factors contribute to its development, but the main culprit is elevated intraocular pressure, that is, pressure within the eye.

Theoretically, glaucoma can be managed and vision loss prevented or minimized with early detection and medical treatment to control intraocular pressure. But the most common form, called open-angle glaucoma, progresses so slowly and subtly that symptoms, such as blind spots and reduced peripheral vision, may go unnoticed until the disease has advanced and vision loss is inevitable.