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Travel disrupts many of the body's natural rhythms, including digestion, increasing the odds of indigestion, diarrhea, or constipation. Food and water in developing countries can be contaminated with germs that make traveler's diarrhea more likely. Tactics to keep "traveler's tummy" at bay include packing over-the-counter digestive aids and familiar snacks, and avoiding street food and local water and ice.

Eating a fiber-rich diet helps to prevent constipation. There are a variety of laxatives for occasional irregularity.

Inflammatory bowel disease, a condition that causes inflammation along the gastrointestinal tract, has a major impact on daily life. For people who identify as LGBTQ+ there are some specific concerns and issues to understand and consider.

The gallbladder stores bile from the liver and squeezes it into the small intestine to help digest fats. About 15% of American adults have gallbladder disease, most commonly gallstones. Women are more prone to gallstones because estrogen slows the gallbladder's ability to empty. Serious complications can result from gallbladder disease, including inflammation, infection, and blockages. People can reduce their risk for gallbladder problems by eating more fruits and vegetables, favoring lean proteins, and maintaining a healthy weight.

Probiotics are good bacteria that keep the gut healthy and help fight infections and inflammation. Some research suggests that certain probiotics help relieve symptoms of gut-related conditions like inflammatory bowel disease and irritable bowel syndrome. Fermented foods are the best sources of probiotics, such as yogurt, pickles, sauerkraut, and sourdough bread.

Some fermented foods contain probiotics, beneficial microorganisms that can live in your intestines. These microorganisms help you stay healthy, potentially improving your immune function and reducing damaging inflammation. Eating prebiotics—high-fiber foods that are a source of nutrition for these healthful microorganisms—is essential to help these beneficial microorganisms grow and thrive.