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If your food is more likely to come out of a bag or a box than from a tree or the ground, you may be putting yourself at higher risk for cancer. A study published online Feb. 14, 2018, by The BMJ found that people who eat more ultra-processed foods have a higher overall risk of cancer than those who don't. In fact, when the proportion of ultra-processed foods in a person's diet increased by 10%, the risk of cancers increased by more than 10%.

The researchers came to their conclusions after reviewing data from more than 100,000 people, on average 42 years old, based on their usual consumption of 3,300 different foods. The foods were classified according to their level of processing. Ultra-processed foods included things like

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Here's another reason to say goodbye to hot dogs, soda, and white bread: A Harvard study published online Jan. 18, 2018, by JAMA Oncology suggests that diets promoting chronic inflammation are associated with colorectal cancer. Researchers analyzed the self-reported eating habits of more than 120,000 men and women, who filled out surveys every four years over a period of 26 years. People in the study who ate the most foods that promoted inflammation � such as red and processed meats, sugary drinks, and refined grains � had a higher rate of colorectal cancer compared with people who ate the least of these foods. For men, the risk was 44% higher; for women, the risk was 22% higher. The people who ate pro-inflammatory diets also ate fewer vegetables and drank less tea, wine, and coffee. A growing number of studies have found that chronic inflammation is associated with cancer. And many other studies have shown links between pro-inflammatory diets and chronic diseases such as type 2 diabetes and heart disease. The bottom line: Anything you can do to reduce the risk of chronic inflammation is a good idea. That could mean cutting out foods that are associated with inflammation, reducing stress, or getting more exercise.

In the journals

A prescription cream called 5-fluorouracil (5-FU, sold as Adrucil and other brands) may help people reduce their risk for squamous cell carcinoma (SCC), according to a study published in the Jan. 3, 2017, JAMA Dermatology. SCC, the second most common cancer in the United States, strikes twice as many men as women.

Researchers recruited 932 people, 98% of whom were men, with an average age of 71. Each had experienced at least two skin cancers � SCC, basal cell carcinoma (BCC, the most common skin cancer), or both � on their face or ears within the past five years. They were randomly assigned to receive either the 5-FU cream or a placebo cream. Everyone applied a thin layer twice a day to their face and ears for up to four weeks. Over the course of a year, the 5-FU group had a 75% lower incidence of SCC compared with the placebo group. They also had a 11% lower incidence of BCC, but this difference was not statistically significant. It's not known why 5-FU helped prevent SCC but not BCC, according to the researchers.

Research we're watching

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Your doctor may one day be able to use a simple blood test to find out if you have cancer. Researchers from Johns Hopkins University reported in the January 19 issue of Science that they have developed a blood test that can spot early signs of cancer.

The researchers screened blood for DNA and proteins related to eight different types of cancer. They were able to identify early cancers from more than 1,000 patients with different types of cancer that had not yet spread. Over all, the test found 33% to 98% of cancers, depending on tumor type.

Combining multiple forms of radiation therapy with hormone treatments lengthens survival in men with aggressive prostate cancer.

Men whose PSA levels continue rising even after surgery or radiation therapy may have a new treatment option with the approval of the drug apalutamide.

Liquid biopsies may offer a less invasive alternative than a traditional biopsy.

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A tissue biopsy is the standard test for identifying cancer. Your medical team will use needles or other devices to capture pieces of actual tumor to see if it's malignant or benign. But another approach, called a liquid biopsy, is less invasive and may provide a diagnosis when a biopsy doesn't.

This test uses a person's blood to look for signs of cells or mutated DNA that a tumor has shed into the bloodstream. "By sampling DNA or circulating tumor cells in the blood, we can predict and monitor responses to cancer treatments without subjecting patients to invasive biopsy procedures � and perhaps detect cancer early, before it has had a chance to spread," says Dr. David Miyamoto, assistant professor of radiation oncology at Harvard Medical School.

Research we're watching

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March is National Colorectal Cancer Awareness month. Have you been screened? Colon cancer is the second leading cause of cancer deaths in the United States, but is also highly preventable through recommended screenings. These screenings enable doctors to spot precancerous lesions that can lead to colon cancer and remove them before they become a problem. Screenings can also find cancers early, when they are most treatable. All people ages 50 to 75 should get recommended colon cancer screenings. Some people should start getting screened earlier if they have certain risk factors for colon cancer, including a family history, a personal history of inflammatory bowel disease (such as Crohn's disease or ulcerative colitis), or a genetic condition that makes colon cancer more likely (such as familial adenomatous polyposis).

There are several tests used for colon cancer screening, including colonoscopy, which uses a device to examine the full length of the colon and rectum; stool tests; flexible sigmoidoscopy, which uses a device to examine a portion of the colon; and CT colonography, a scanning technique that produces images of the colon that are examined by the doctor.