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Rheumatoid arthritis (RA) affects two to three times as many women as men. Scientists are uncovering RA's potential genetic and hormonal underpinnings, which point to potential reasons why women are more vulnerable. The newest treatments, called Janus kinase (JAK) inhibitors, resulted from research that has teased out delicate differences in immune system pathways. They block numerous proteins that ramp up inflammation fundamental to RA. The wide array of drug options now available for RA help doctors personalize therapies to each patient.

Some people have poor circulation, but if your fingers pale and go numb when exposed to quick changes in temperature, it could be Raynaud's phenomenon, a different kind of circulation problem. Generally, avoiding sudden exposure to cold and other factors that cause blood vessels to constrict, and being prepared with gloves and extra layers of clothing, helps.

People with autoimmune diseases may be up to three times more likely to develop cardiovascular disease than people without an autoimmune disease. Among the most common autoimmune diseases are rheumatoid arthritis, psoriasis, and lupus. Awareness of this elevated risk is especially important because autoimmune disease typically strikes when people are in their 20s or 30s. In turn, heart problems may develop up to a decade earlier than in people without an autoimmune disease. A calcium scan, which detects early signs of atherosclerosis, can help assess a person's risk and guide treatment advice.

Genes that helped people survive during the time of the Black Death are more likely to be found in people with autoimmune diseases alive today. Does this tell scientists anything about what surviving the COVID-19 pandemic might mean for the world's population?

An estimated 7% of Americans have an autoimmune disorder, and these tend to disproportionately affect women. Expert guidelines can help with questions about the best birth control options for people with lupus and other autoimmune diseases.

Sugar is a carbohydrate that provides the body with energy and has an important role in nutrition. It is found in many healthy whole foods, but it is also abundant in unhealthy processed foods. The problem many people have with sugar is that they consume too much of the refined kind added to many processed food products, and not enough of the natural kind in fruits, vegetables, and grains.

There are several types of "sun allergies," including polymorphous light eruption (PMLE), hives, and photoallergic reactions. Learn about these different reactions to sun exposure, as well as prevention and treatment.