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On October 16, 1846, , a renowned surgeon at , removed a tumor from a printer named Gilbert Abbott. The operation was noteworthy for one reason: Abbott did not scream out in pain, as virtually every surgical patient did in those days.

. A Boston dentist, , had designed a device that enabled Abbott to inhale ether until he became unconscious. Although Abbott mumbled a few times during surgery, when he woke up he told his physicians that he remembered feeling only mild discomfort.

The occasion was so momentous that the operating theater where Abbott’s surgery took place is now known as the , and each year Mass. General celebrates . The ether demonstration was also immortalized in a by that now hangs in the lobby of Harvard’s (see image below), just one floor down from where Ì첩ÌåÓý Publishing is located.

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Of course, human nature being what it is, almost immediately after ether’s painkilling powers were discovered, ordinary people started inhaling the gas on their own, to get high. Raucous “� became all the rage. (And you thought the Victorians were uptight!)

Fast forward 150 years or so, and the drug names may have changed, but the potential for drug abuse has not. Anesthesia has moved beyond ether, and a wide variety of painkillers are now available to treat pain from surgery, cancer, and chronic conditions like arthritis.

Narcotic painkillers, such as oxycodone (OxyContin), hydrocodone (Vicodin), and meperidine (Demerol) are among the most powerful painkillers available. These drugs belong to a class known as opioid analgesics, and they act on the same receptors in the brain as heroin does. Just as in the ether frolics of the last century, some people are using opioid painkillers for nonmedical reasons, to attain a drug-induced euphoria. Unfortunately, some people become addicted to painkillers as a result.

The Centers for Disease Control and Prevention that emergency room visits for drug reactions following nonmedical use of narcotic painkillers increased 111% over a five-year period, from 2004 to 2008. The 2009 found that nearly two million Americans were dependent on or abusing prescription pain relievers—five times greater than the number of people addicted to heroin. Opioid painkiller addiction was also more common than abuse or dependence on any other type of prescription drug.

We’re working on a story about opioid painkiller addiction for an upcoming issue of the Harvard Mental Health Letter. We’ll discuss treatment options and challenges. In the meantime, if you are interested in learning more about painkiller addiction, you might want to read some of the articles published on this topic in the mainstream media. Both and have covered the topic in depth, as have and .

NPR also ran a story about a journalist who became addicted to painkillers, broke the habit, and decided to . If you know someone who has become addicted to painkillers, or who has benefited from treatment, feel free to share your story in our comments section.

Editor’s note: Research assistance for this blog provided by Aviva Schwartz.