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I received my undergraduate and medical degree from Boston University. I then completed a neurology residency at the University of Pittsburgh, followed by a dementia and behavioral neuroscience fellowship at the University of California, Los Angeles. I am board certified in Neurology. I am currently the Director of Clinical Trials at the Center for Alzheimer Research and Treatment at Brigham and Women’s Hospital; Associate Neurologist at Brigham and Women’s Hospital; Assistant in Neurology at Massachusetts General Hospital; and Associate Professor of Neurology at Harvard Medical School. Over the past 17 years, I have focused on improving the clinical care of patients with Alzheimer’s disease (AD) and related conditions, in conjunction with clinical research in AD. Over the past 14 years, I have been site principal investigator for 14 clinical trials and 4 observational imaging studies in AD and am currently the site principal investigator for the Alzheimer’s Disease Neuroimaging Initiative (ADNI) 3 and the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Disease (A4) trial. My NIH-funded research has focused on clinical correlates of instrumental activities of daily living and neuropsychiatric symptoms with amyloid, tau, and FDG PET, structural and resting-state functional MRI, and CSF biomarkers across the early AD spectrum. More recently, I have been developing novel sensitive performance-based instrumental activities of daily living tests for early-stage AD.